Aquaporin-4 autoantibody: a neurogenic cause of anorexia and weight loss
نویسندگان
چکیده
منابع مشابه
Anorexia and weight loss in older persons.
UNINTENTIONAL weight loss represents a cardinal symptom of frailty in older persons (1–6). Even a small decline in body mass in older persons is associated with mortality (7). Protein energy malnutrition is associated with anemia, pressure ulcers, sarcopenia, bone loss and hip fractures, declining immune function, impaired immune response to vaccinations, infections, cognitive impairment, funct...
متن کاملDiseases of the alimentary system. Anorexia and loss of weight.
I Hoff, J, Spetzler, R, and Winestock, D, in press. 2 Klinger, M, et al, Journal of Neurology, Neurosurgery and Psychiatry, 1975, 38, 272. 3 Talalla, A, and Morin, M A,Journal of Trauma, 1971, 2, 771. 4Paxton, R, and Ambrose, J, British Journal of Radiology, 1974, 47, 530. 5Richardson, A, in Handbook of Clinical Neurology, ed P J Vinken and G W Bruyn, Vol 23, part 1, p. 255. Amsterdam, North Ho...
متن کاملAcute vascular disruption and aquaporin 4 loss after stroke.
BACKGROUND AND PURPOSE Ischemic protection has been demonstrated by a decrease in stroke-infarct size in transgenic mice with deficient Aquaporin 4 (AQP4) expression. However, it is not known whether AQP4 is rapidly reduced during acute stroke in animals with normal AQP4 phenotype, which may provide a potential self-protective mechanism. METHODS Adult male rats underwent transient occlusion o...
متن کاملLeptin-induced weight loss is not solely mediated by anorexia.
The discovery of the ob-gene product leptin in 1994 (1 –2) and the subsequent identification of grossly obese children lacking leptin (3) or its receptor (4) considerably increased the expectation of finding an effective cure for grossly obese humans. Very soon after its discovery it became evident, however, that a deficiency of leptin did not account for obesity in the large majority of patien...
متن کاملEvaluation of Clinical Interest of Anti-Aquaporin-4 Autoantibody Followup in Neuromyelitis Optica
Neuromyelitis optica (NMO) is an autoimmune disease in which a specific biomarker named NMO-IgG and directed against aquaporin-4 (AQP4) has been found. A correlation between disease activity and anti-AQP4 antibody (Ab) serum concentration or complement-mediated cytotoxicity has been reported, but the usefulness of longitudinal evaluation of these parameters remains to be evaluated in actual cli...
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ژورنال
عنوان ژورنال: Developmental Medicine & Child Neurology
سال: 2011
ISSN: 0012-1622
DOI: 10.1111/j.1469-8749.2011.04099.x